{"id":188,"date":"2018-12-16T11:22:51","date_gmt":"2018-12-16T11:22:51","guid":{"rendered":"http:\/\/www.resitozkanca.org\/?p=188"},"modified":"2025-10-21T10:46:26","modified_gmt":"2025-10-21T10:46:26","slug":"neden-bazi-insanlar-clostridium-difficileye-karsi-daha-duyarlidir","status":"publish","type":"post","link":"http:\/\/www.resitozkanca.com.tr\/?p=188","title":{"rendered":"Neden Baz\u0131 \u0130nsanlar Clostridium difficile\u2019ye Kar\u015f\u0131 Daha Duyarl\u0131d\u0131r ?"},"content":{"rendered":"

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Clostridioides difficile<\/em><\/strong> \u00a0bazen \u015fiddetli olabilen ve hayati tehlike olu\u015fturabilen f\u0131rsat\u00e7\u0131 bir intestinal patojendir..<\/p>\n

\"102418_ti_c-difficile_feat_free<\/p>\n

Farelerde yap\u0131lan \u00e7al\u0131\u015fmalarda, fare\u00a0 ba\u011f\u0131rsa\u011f\u0131ndaki mikrofloran\u0131n \u00a0bozulmas\u0131 sonucu\u00a0 C. difficile<\/em> enfeksiyonlar\u0131n\u0131n ortaya \u00e7\u0131kt\u0131\u011f\u0131 g\u00f6r\u00fclm\u00fc\u015ft\u00fcr. Science Translational Medicine’<\/strong> de yay\u0131nlanan verilere g\u00f6re \u00a0ABD’de Hastal\u0131k Kontrol ve \u00d6nleme Merkezleri 1 y\u0131lda, 1000 ki\u015fiden 148’inde, daha \u00f6nce Clostridium difficile<\/em><\/strong> enfeksiyonlar\u0131 olarak bilinen C. difficile<\/strong><\/em>‘nin geli\u015fti\u011fi tahmin edilmektedir. Bu t\u00fcr enfeksiyonlar genellikle insanlar\u0131n antibiyotik kulland\u0131ktan sonra bozulan ba\u011f\u0131rsak microfloras\u0131n\u0131n ard\u0131ndan geli\u015fti\u011fi bilinmektedir.<\/p>\n

Rochester’daki Mayo Klini\u011fi Gastroenterolog Purna Kashyap, Minn. ve arkada\u015flar\u0131, farelere normal veya ba\u011f\u0131rsak floras\u0131 bozulan olan insanlardan d\u0131\u015fk\u0131y\u0131 transplante eden deneyler yapt\u0131lar. Normal ba\u011f\u0131rsak mikrobiyomlar\u0131 olan insanlardan nakil yap\u0131lan farelerin, , mikrofloras\u0131 bozulan insanlardan nakil alan farelere g\u00f6re C. difficile<\/em><\/strong> enfeksiyonlar\u0131na kar\u015f\u0131 daha g\u00fc\u00e7l\u00fc sava\u015ft\u0131\u011f\u0131 belirlendi. .<\/p>\n

Ayr\u0131ca ba\u011f\u0131rsaklardaki mikroflora de\u011fi\u015fimleri sonucu, ba\u011f\u0131rsaktaki belirli amino asitlerin, \u00f6zellikle prolin miktar\u0131nda belirgin bir art\u0131\u015f oldu\u011fu belirlenmi\u015ftir. C. difficile<\/em><\/strong>, prolini ana besin kayna\u011f\u0131 olarak kullan\u0131p, bu amino asidi kolayca t\u00fcketmeyen mikroplar \u00fczerinde rekabet avantaj\u0131 sa\u011flar. Ara\u015ft\u0131rmac\u0131lar, bir prolin eksikli\u011fi olan fare yemi ile beslenen farelerin ba\u011f\u0131rsaklar\u0131nda normal bir diyette fareler olarak \u00e7ok daha az C. difficile<\/em><\/strong> bakterisi bulundu\u011funu tesbit etti. B\u00f6yle bir enfeksiyon durumunda ba\u011f\u0131rsakta prolin t\u00fcketen di\u011fer bakterilerin bulunmas\u0131 C.difficile<\/strong><\/em> ile yap\u0131lan m\u00fccadeleyi kolayla\u015ft\u0131raca\u011f\u0131 d\u00fc\u015f\u00fcn\u00fclmektedir.<\/p>\n","protected":false},"excerpt":{"rendered":"

  Clostridioides difficile \u00a0bazen \u015fiddetli olabilen ve hayati tehlike olu\u015fturabilen f\u0131rsat\u00e7\u0131 bir intestinal patojendir.. Farelerde yap\u0131lan \u00e7al\u0131\u015fmalarda, fare\u00a0 ba\u011f\u0131rsa\u011f\u0131ndaki mikrofloran\u0131n \u00a0bozulmas\u0131 sonucu\u00a0 C. difficile enfeksiyonlar\u0131n\u0131n ortaya \u00e7\u0131kt\u0131\u011f\u0131 g\u00f6r\u00fclm\u00fc\u015ft\u00fcr. Science Translational Medicine’ de yay\u0131nlanan verilere g\u00f6re \u00a0ABD’de Hastal\u0131k Kontrol ve \u00d6nleme Merkezleri 1 y\u0131lda, 1000 ki\u015fiden 148’inde, daha \u00f6nce Clostridium difficile enfeksiyonlar\u0131 olarak bilinen C. difficile‘nin … <\/p>\n

Okumaya devam et “Neden Baz\u0131 \u0130nsanlar Clostridium difficile\u2019ye Kar\u015f\u0131 Daha Duyarl\u0131d\u0131r ?”<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-188","post","type-post","status-publish","format-standard","hentry","category-genel-bilimsel-gelismeler"],"_links":{"self":[{"href":"http:\/\/www.resitozkanca.com.tr\/index.php?rest_route=\/wp\/v2\/posts\/188","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.resitozkanca.com.tr\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.resitozkanca.com.tr\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.resitozkanca.com.tr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.resitozkanca.com.tr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=188"}],"version-history":[{"count":1,"href":"http:\/\/www.resitozkanca.com.tr\/index.php?rest_route=\/wp\/v2\/posts\/188\/revisions"}],"predecessor-version":[{"id":189,"href":"http:\/\/www.resitozkanca.com.tr\/index.php?rest_route=\/wp\/v2\/posts\/188\/revisions\/189"}],"wp:attachment":[{"href":"http:\/\/www.resitozkanca.com.tr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=188"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.resitozkanca.com.tr\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=188"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.resitozkanca.com.tr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=188"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}